gamma globin การใช้

• The precise mechanism of action is not yet clear, but it appears that hydroxycarbamide increases nitric oxide levels, causing soluble guanylyl cyclase activation with a resultant rise in cyclic GMP, and the activation of gamma globin gene expression and subsequent gamma chain synthesis necessary for fetal hemoglobin ( HbF ) production ( which inhibits the polymerization sickle hemaoglobin ( HbSS ) leading to the deformation of red blood cells recognized as sickled cells.